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副作用最多见于临床试验中的味觉改变或味觉障碍（比如口中含有苦味或金属味）通常这种味觉改变是短暂的，能持续至该药物的半衰期过期。
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/Investigators/ noticed variations from the metabolism of diazepam in Wistar rats. /The authors/ researched these variants thoroughly, and located that the versions are dimorphic and about seventeen% of male Wistar rats examined confirmed two moments larger diazepam metabolic activities inside their liver microsomes than the remainder of animals at the substrate concentrations less than five uM. /They were/ categorised as intensive metabolizer and inadequate metabolizer of diazepam. No sex distinction was noticed in the frequency of visual appeal of in depth metabolizer. Actions of the principal metabolic pathways of diazepam ended up examined to elucidate the website cause of this polymorphism in male Wistar rats. No sizeable differences were being observed in functions of neither diazepam 3-hydroxylation or N-desmethylation among extensive metabolizer and weak metabolizer rats, whilst activity of diazepam p-hydroxylation was markedly (more than 200 occasions) increased in extensive metabolizer rats, indicating this response is chargeable for the polymorphism of diazepam metabolism in Wistar rats. We examined the expression amounts of CYP2D1, which was reported to catalyze diazepam p-hydroxylation in Wistar rats to seek out no differences during the expression amounts of CYP2D1 concerning extensive metabolizer and PM rats.
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